Arber lab
Our overall goal is to develop novel targeted immunotherapies for patients with hematologic malignancies. The group develops adoptive T cell therapies with native or engineered receptors and evaluates combinatorial strategies. The objective is to efficiently target tumor cells, mitigate immunosuppressive tumor microenvironment factors, favor tumor-targeted migration and longevity of transferred T cells, control potential toxicities, identify novel personalized targets, and move developments to the clinic. ...
Research projects
Please check back later to discover our ongoing projects.
Latest publications
Novel strategies to manage CAR-T cell toxicity.
Mulvey A, Trueb L, Coukos G, Arber C
Nature reviews. Drug discovery – 2025 Feb 3
Choice of commercially available CAR-T cell products for r/r DLBCL & PMBCL in Europe: a survey on behalf of the cellular therapy & immunobiology working party (CTIWP) of the EBMT.
Novak U, Mooyaart JE, Daskalakis M, (...), Kuball J, Ruggeri A, Malard F
Bone marrow transplantation – 2024 Aug 27
Two to tango: engineered T cells against AML.
Arber C
Blood – 2024 Feb 8
Hematopoietic cell transplantation and cellular therapies in Switzerland. Evolution over 25 years.
Passweg JR, Baldomero H, Ansari M, Wannesson L, Halter JP
Hematological oncology – 2023 Dec 6
Computational design of dynamic receptor-peptide signaling complexes applied to chemotaxis.
Jefferson RE, Oggier A, Füglistaler A, (...), Villarreal AR, Arber C, Barth P
Nature communications – 2023 May 19
Team
Other members
Alumni
Hello this is the alumni part
Jean pierre
Bobby
Samy
Selected Publications
Reductive carboxylation epigenetically instructs T cell differentiation.
Jaccard A, Wyss T, Maldonado-Pérez N, (...), Romero P, Ho PC, Wenes M
Nature – 2023 Sep 20
Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring
Perez C, Gruber I, Arber C
Frontiers in immunology – 2020 Nov 11
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.
Rath JA, Bajwa G, Carreres B, (...), Brenner MK, Gfeller D, Arber C
Science advances – 2020 Jul 3
Engineering Strategies to Enhance TCR-Based Adoptive T Cell Therapy.
Rath JA, Arber C
Cells – 2020 Jun 18
c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals.
Nishimura CD, Brenner DA, Mukherjee M, (...), Brenner MK, Lin CY, Arber C
Blood – 2017 Oct 27
Reprogramming cellular functions with engineered membrane proteins.
Arber C, Young M, Barth P
Current opinion in biotechnology – 2017 Jul 11
CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia.
Bonifant CL, Szoor A, Torres D, (...), Song XT, Redell M, Gottschalk S
Molecular therapy : the journal of the American Society of Gene Therapy – 2016 Jun 6
Survivin-specific T cell receptor targets tumor but not T cells.
Arber C, Feng X, Abhyankar H, (...), Barth P, Dotti G, Savoldo B
The Journal of clinical investigation – 2014 Nov 21
Mouse models in bone marrow transplantation and adoptive cellular therapy.
Arber C, Brenner MK, Reddy P
Seminars in hematology – 2013 Jun 11
The immunogenicity of virus-derived 2A sequences in immunocompetent individuals.
Arber C, Abhyankar H, Heslop HE, (...), Liu H, Dotti G, Savoldo B
Gene therapy – 2013 May 23
Graft source determines human hematopoietic progenitor distribution pattern within the CD34(+) compartment.
Arber C, Halter J, Stern M, (...), Rovó A, Gratwohl A, Tichelli A
Bone marrow transplantation – 2010 Aug 16
Black hole in the lung.
Cantoni N, Weisser M, Frei R, Lardinois D, Arber C
Bone marrow transplantation – 2010 Mar 29
Platelet refractoriness due to combined anti-HLA and anti-HPA-5a alloantibodies: clinical management during myeloablative allogeneic HSCT and development of a quantitative MAIPA assay.
Arber C, Bertrand G, Halter J, (...), Boehlen F, Kaplan C, Gratwohl A
British journal of haematology – 2007 Oct
Septic polyarthritis with Ureaplasma urealyticum in a patient with prolonged agammaglobulinemia and B-cell aplasia after allogeneic HSCT and rituximab pretreatment.
Arber C, Buser A, Heim D, (...), Tichelli A, Passweg J, Gratwohl A
Bone marrow transplantation – 2007 Jul 9
Cyclosporine-responsive thrombocytopenia in a patient with chloramphenicol-associated myelodysplastic syndrome.
Arber C, Buser A, Heim D, (...), Gratwohl A, Tichelli A, Passweg JR
European journal of haematology – 2006 Mar
Related news
Events
🌱 2nd AGORA Sustainability Day | May 21st
Events
AGORA PRS Seminar | April 29th
Events
LabLinks: Tumor immunology and immunotherapy | November 11&12th
Events
13th Faculty & Staff Annual Retreat, Swiss Cancer Center Leman | September 26 & 27
Events
Ludwig Distinguished Lecture, Prof. Michael Dustin | December 16th
Events
